Medicine and Health

Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse

X. Ye, W. Chen, et al.

Discover how cyanidin-3-O-glucoside (C3G), an anthocyanin from red bayberry, could revolutionize diabetes treatment! Researchers Xiang Ye, Wen Chen, Xu-Fan Huang, Fu-Jie Yan, Shui-Guang Deng, Xiao-Dong Zheng, and Peng-Fei Shan have revealed C3G's potential in enhancing insulin sensitivity and reducing blood sugar levels in diabetic models. Don't miss out on this exciting development!

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Abstract

This study investigated the anti-diabetic effect of cyanidin-3-O-glucoside (C3G), an anthocyanin extracted from red bayberry. In vitro experiments using insulin-resistant HepG2 and L02 cells showed that C3G increased glucose consumption, glycogen synthesis, and insulin sensitivity by inhibiting protein tyrosine phosphatase 1B (PTP1B) and increasing phosphorylation of insulin receptor substrate 2 (IRS-2). In vivo studies using diabetic db/db mice demonstrated that C3G administration reduced fasting blood glucose levels and improved glucose tolerance and insulin resistance. These findings suggest that C3G may be a potential therapeutic agent for type 2 diabetes mellitus.

Publisher

Nutrition and Diabetes

Published On

Mar 01, 2024

Authors

Xiang Ye, Wen Chen, Xu-Fan Huang, Fu-Jie Yan, Shui-Guang Deng, Xiao-Dong Zheng, Peng-Fei Shan

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