Medicine and Health

A population-scale analysis of 36 gut microbiome studies reveals universal species signatures for common diseases

W. Sun, Y. Zhang, et al.

Delve into groundbreaking research by Wen Sun and colleagues as they uncover the intricate relationship between gut microbiome diversity and various diseases. This comprehensive study of 6314 fecal metagenomes reveals profound insights into disease-associated species and holds promise for personalized disease management.

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Playback language: English

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Abstract

This study reanalyzed 6314 fecal metagenomes from 36 case-control studies to investigate gut microbiome diversity and disease-shared signatures. Reduced microbial diversity was observed in many diseases, with significant alterations in microbial communities across most. A meta-analysis identified 277 disease-associated species, including opportunistic pathogens enriched in patients and protective species in controls. This research offers insights into the gut microbiome's role in common diseases and potential for personalized disease management.

Publisher

npj Biofilms and Microbiomes

Published On

Oct 01, 2024

Authors

Wen Sun, Yue Zhang, Ruochun Guo, Shanshan Sha, Changming Chen, Hayan Ullah, Yan Zhang, Jie Ma, Wei You, Jinxin Meng, Qingbo Lv, Lin Cheng, Shao Fan, Rui Li, Xiaohong Mu, Shenghui Li, Qiulong Yan

DOI

https://doi.org/10.1038/s41522-024-00567-9

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