This study reanalyzed 6314 fecal metagenomes from 36 case-control studies to investigate gut microbiome diversity and disease-shared signatures. Reduced microbial diversity was observed in many diseases, with significant alterations in microbial communities across most. A meta-analysis identified 277 disease-associated species, including opportunistic pathogens enriched in patients and protective species in controls. This research offers insights into the gut microbiome's role in common diseases and potential for personalized disease management.
Publisher
npj Biofilms and Microbiomes
Published On
Oct 01, 2024
Authors
Wen Sun, Yue Zhang, Ruochun Guo, Shanshan Sha, Changming Chen, Hayan Ullah, Yan Zhang, Jie Ma, Wei You, Jinxin Meng, Qingbo Lv, Lin Cheng, Shao Fan, Rui Li, Xiaohong Mu, Shenghui Li, Qiulong Yan
