Biology

All-optical voltage interrogation for probing synaptic plasticity in vivo

J. Carolan, M. A. Land, et al.

An all-optical approach records sub- and suprathreshold signals in Purkinje cell dendrites while selectively activating granule cell inputs and sensory-evoked climbing fibers, showing that pairing these inputs can induce long-term plasticity of inhibitory responses. Research conducted by Jacques Carolan, Michelle A. Land, Xiaoyu Lu, Maxime Beau, Dimitar Kostadinov, François St-Pierre, Beverley A. Clark, and Michael Häusser.