Medicine and Health

Adipocytes control food intake and weight regain via Vacuolar-type H⁺ ATPase

R. C. Zapata, M. Carretero, et al.

This innovative study delves into the molecular mechanisms of weight regain after obesity-induced weight loss, revealing that 'metabolic memory' resides in adipocytes. Researchers highlighted *ATP6v0al*, a key regulator identified in a *C. elegans* screen, as a promising therapeutic target for obesity, based on findings from a team led by Rizaldy C. Zapata and Maria Carretero.

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Abstract

This study investigates the molecular mechanisms underlying weight regain after weight loss in obesity. Using a mouse model of diet-induced obesity and weight loss, the researchers found that "metabolic memory" of obesity is primarily localized in adipocytes. A *C. elegans* screen identified *ATP6v0al*, a V-ATPase subunit, as a key regulator of food intake. Adipocyte-specific *Atp6v0a1* knockout mice exhibited reduced food intake and weight gain. Pharmacological V-ATPase inhibition also led to decreased food intake and less weight regain. These findings suggest *ATP6v0al* as a potential therapeutic target for obesity.

Publisher

Nature Communications

Published On

Aug 30, 2022

Authors

Rizaldy C. Zapata, Maria Carretero, Felipe Castellani Gomes Reis, Besma S. Chaudry, Jachelle Ofrecio, Dinghong Zhang, Roman Sasik, Theodore Ciaraldi, Michael Petrascheck, Olivia Osborn

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