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Abrupt termination of vitamin C from ICU patients may increase mortality: secondary analysis of the LOVIT trial

Medicine and Health

Abrupt termination of vitamin C from ICU patients may increase mortality: secondary analysis of the LOVIT trial

H. Hemilä and E. Chalker

This study by Harri Hemilä and Elizabeth Chalker explores the implications of abruptly stopping vitamin C treatment in critically ill patients. While initial results showed no significant impact on mortality during the treatment period, an alarming increase in mortality was observed following cessation. Discover the critical insights from this secondary analysis of the LOVIT trial.

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Playback language: English
Abstract
This secondary analysis of the LOVIT trial investigated whether the abrupt cessation of vitamin C administration contributed to increased mortality in the vitamin C group. Using Cox regression, the study found no difference in mortality between the vitamin C and placebo groups during the 4-day treatment period. However, a significant increase in mortality (RR = 1.9, 95% CI: 1.2–2.9; p = 0.004) was observed in the vitamin C group during the week following the abrupt termination of vitamin C. The authors conclude that the increased mortality is attributable to the abrupt cessation, not the vitamin C itself, and that the LOVIT trial's findings should not be interpreted as evidence against vitamin C therapy for critically ill patients.
Publisher
European Journal of Clinical Nutrition
Published On
Authors
Harri Hemilä, Elizabeth Chalker
DOI
https://doi.org/10.1038/s41430-022-01254-8
Tags
vitamin C
mortality
LOVIT trial
critically ill patients
Cox regression
secondary analysis

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