This study introduces a bifunctional small molecule, conjugating the neuraminidase inhibitor zanamivir with the immunogenic hapten dinitrophenyl (DNP), to simultaneously inhibit virus release and trigger immune-mediated elimination of free virus and infected cells. A single dose eradicated advanced infections in mice infected with influenza A and B viruses, even when administered up to three days post-infection, suggesting potential for treating infections unresponsive to current therapies.
Publisher
Nature Communications
Published On
Nov 05, 2020
Authors
Xin Liu, Boning Zhang, Yingcai Wang, Hanan S Haymour, Fenghua Zhang, Le-cun Xu, Madduri Srinivasarao, Philip S Low
Tags
bifunctional small molecule
neuraminidase inhibitor
zanamivir
immunogenic hapten
dinitrophenyl
influenza
virus elimination
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