Medicine and Health

A universal dual mechanism immunotherapy for the treatment of influenza virus infections

X. Liu, B. Zhang, et al.

This groundbreaking study reveals a novel bifunctional small molecule that combines the power of the neuraminidase inhibitor zanamivir with the immunogenic hapten dinitrophenyl (DNP). The findings demonstrate its capability to not only inhibit virus release but also to activate immune responses to eliminate both free viruses and infected cells. Conducted by a team of researchers at Purdue University, this research showcases potential treatments for influenza A and B infections that are resistant to current therapies.

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Abstract

This study introduces a bifunctional small molecule, conjugating the neuraminidase inhibitor zanamivir with the immunogenic hapten dinitrophenyl (DNP), to simultaneously inhibit virus release and trigger immune-mediated elimination of free virus and infected cells. A single dose eradicated advanced infections in mice infected with influenza A and B viruses, even when administered up to three days post-infection, suggesting potential for treating infections unresponsive to current therapies.

Publisher

Nature Communications

Published On

Nov 05, 2020

Authors

Xin Liu, Boning Zhang, Yingcai Wang, Hanan S Haymour, Fenghua Zhang, Le-cun Xu, Madduri Srinivasarao, Philip S Low

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