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A sustainable synthesis of the SARS-CoV-2 Mpro inhibitor nirmatrelvir, the active ingredient in Paxlovid

Chemistry

A sustainable synthesis of the SARS-CoV-2 Mpro inhibitor nirmatrelvir, the active ingredient in Paxlovid

J. R. A. Kincaid, J. C. Caravez, et al.

This groundbreaking research by Joseph R. A. Kincaid, Juan C. Caravez, Karthik S. Iyer, Rahul D. Kavthe, Nico Fleck, Donald H. Aue, and Bruce H. Lipshutz unveils a new 7-step synthetic approach to nirmatrelvir, the key component in Paxlovid, achieving an impressive 70% overall yield while utilizing green technology.

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