Medicine and Health

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity

W. Chen, A. Hajduczki, et al.

Discover how nurse sharks, through innovative immunization, produced powerful antibodies that neutralized SARS-CoV-2 variants, including Omicron! This groundbreaking research conducted by a team of experts from the Walter Reed Army Institute of Research and the University of Maryland holds promise for developing new immunotherapeutics.

00:00

Playback language: English

Index

Abstract

Despite ongoing vaccine and therapeutic development, SARS-CoV-2 continues to evolve. Nurse sharks immunized with SARS-CoV-2 antigens produced IgNAR antibodies targeting conserved spike RBD epitopes. These shark antibodies (ShAbs) potently neutralized SARS-CoV-2 variants, including Omicron, and protected mice from SARS-CoV-2 challenge. Structural analysis enabled the design of multi-specific nanobodies with enhanced neutralization and picomolar affinity to sarbecoviruses. These shark nanobodies are potential immunotherapeutics.

Publisher

Nature Communications

Published On

Feb 03, 2023

Authors

Wei-Hung Chen, Agnes Hajduczki, Elizabeth J Martinez, Hongjun Bai, Hanover Matz, Thomas M Hill, Eric Lewitus, William C Chang, Layla Dawit, Caroline E Peterson, Phyllis A Rees, Adelola B Ajayi, Emily S Golub, Isabella Swafford, Vincent Dussupt, Sapna David, Sandra V Mayer, Sandrine Soman, Caitlin Kuklis, Courtney Corbitt, Jocelyn King, Misook Choe, Rajeshwer S Sankhala, Paul V Thomas, Michelle Zemil, Lindsay Wieczorek, Tricia Hart, Debora Duso, Larry Kummer, Lianying Yan, Spencer L Sterling, Eric D Laing, Christopher C Broder, Jazmean K Williams, Edgar Davidson, Benjamin J Doranz, Shelly J Krebs, Victoria R Polonis, Dominic Paquin-Proulx, Morgane Rolland, William W Reiley, Gregory D Gromowski, Kayvon Modjarrad, Helen Dooley, M Gordon Joyce

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

D. Sun, Z. Sang, et al.

Medicine and Health

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

Y. Guo, G. Zhang, et al.

Medicine and Health

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

T. Li, X. Han, et al.

Medicine and Health

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

X. Zhang, H. Zhang, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny