Medicine and Health

A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation

R. Das, J. Giri, et al.

This groundbreaking study reveals that adipogenic differentiation of visceral adipose tissue-resident multipotent mesenchymal stromal cells (VA-MSC) is hindered by the interaction of key inhibitors IFNγ and TGFβ. Researchers identified a complex mechanism involving STAT5 and Smad3 that maintains MSC plasticity, with implications for metabolic health. The research was conducted by Rahul Das, Jayeeta Giri, Pradyut K. Paul, Nicole Froelich, Raghavan Chinnadurai, Sara McCoy, Wade Bushman, and Jacques Galipeau.