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Abstract
This study presents the development of a replication-competent recombinant VSV-ΔG-spike vaccine, replacing the VSV glycoprotein with the SARS-CoV-2 spike protein. In vitro characterization showed spike protein expression and antigenic similarity to SARS-CoV-2. A single dose in golden Syrian hamsters induced neutralizing antibodies and protected against SARS-CoV-2 challenge, evidenced by reduced weight loss and tissue damage. The vaccine is suggested as a safe and effective option against SARS-CoV-2.
Publisher
Nature Communications
Published On
Dec 16, 2020
Authors
Yfat Yahalom-Ronen, Hadas Tamir, Sharon Melamed, Boaz Politi, Ohad Shifman, Hagit Achdout, Einat B. Vitner, Ofir Israeli, Elad Milrot, Dana Stein, Inbar Cohen-Gihon, Shlomi Lazar, Hila Gutman, Itai Glinert, Lilach Cherry, Yaron Vagima, Shirley Lazar, Shay Weiss, Amir Ben-Shmuel, Roy Avraham, Reut Puni, Edith Lupu, Elad Bar-David, Assa Sittner, Noam Erez, Ran Zichel, Emanuelle Mamroud, Ohad Mazor, Haim Levy, Orly Laskar, Shmuel Yitzhaki, Shmuel C. Shapira, Anat Zvi, Adi Beth-Din, Nir Paran, Tomer Israely
Tags
VSV-ΔG-spike vaccine
SARS-CoV-2
neutralizing antibodies
vaccine efficacy
animal models

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