Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. This study, an 8.6-month, four-arm randomized controlled trial (Aerobic exercise, Diet, Aerobic exercise + Diet, No intervention), analyzed gut microbiota composition in participants who completed the trial. Combined aerobic exercise and diet intervention were associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increased network connectivity and robustness between taxa. Personalized gut microbial networks at baseline could predict individual responses in liver fat to exercise intervention. Findings suggest avenues for developing personalized NAFLD intervention strategies based on host-gut microbiome interactions, but larger studies are needed.
Publisher
Nature Communications
Published On
May 10, 2022
Authors
Runtan Cheng, Lu Wang, Shenglong Le, Yifan Yang, Can Zhao, Xiangqi Zhang, Xin Yang, Ting Xu, Leiting Xu, Petri Wiklund, Jun Ge, Dajiang Lu, Chenhong Zhang, Luonan Chen, Sulin Cheng
Tags
nonalcoholic fatty liver disease
gut microbiota
exercise intervention
diet intervention
personalized strategies
prediabetes
keystone taxa
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