Medicine and Health

A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer's disease

J. Wang, P. Shangguan, et al.

This groundbreaking research by Jiefei Wang and colleagues presents a novel near-infrared-II aggregation-induced emission (AIE) nanotheranostic aimed at combating Alzheimer's disease. It effectively penetrates the blood-brain barrier, binds to amyloid-beta plaques, and utilizes reactive oxygen species to mitigate plaque formation and inflammation, enhancing cognitive functions in a female AD mouse model.

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Abstract

Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of Alzheimer's disease (AD). This research designs a near-infrared-II aggregation-induced emission (AIE) nanotheranostic for precise AD therapy. The nanotheranostic's in vivo BBB penetration and specific plaque binding are monitored, and ROS triggers the release of two AIE molecules to inhibit Aβ fibril formation, degrade Aβ fibrils, prevent reaggregation, scavenge ROS, and alleviate inflammation. This leads to behavioral and cognitive improvements in a female AD mouse model.

Publisher

Nature Communications

Published On

Jan 24, 2024

Authors

Jiefei Wang, Ping Shangguan, Xiaoyu Chen, Yong Zhong, Ming Lin, Mu He, Yisheng Liu, Yuan Zhou, Xiaobin Pang, Lulu Han, Mengya Lu, Xiao Wang, Yang Liu, Huiqing Yang, Jingyun Chen, Chenhui Song, Jing Zhang, Xin Wang, Bingyang Shi, Ben Zhong Tang

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