Oxidative stress contributes to various inflammatory diseases, but clinical treatments remain limited. This study introduces ultrasmall Cu₅₄₀ nanoparticles (Cu₅₄₀ USNPs) as enzyme-mimicking nanozymes with broad-spectrum reactive oxygen species (ROS) scavenging ability. Cu₅₄₀ USNPs exhibit catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking properties, demonstrating cytoprotective effects at low dosages and improving outcomes in acute kidney injury, acute liver injury, and wound healing. Their ultrasmall size allows for rapid renal clearance and biocompatibility. The results highlight the potential of Cu₅₄₀ USNPs for clinical treatment of ROS-related diseases.
