Medicine and Health

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

T. Liu, B. Xiao, et al.

Discover the groundbreaking potential of ultrasmall Cu₅₄₀ nanoparticles (Cu₅₄₀ USNPs) as innovative nanozymes that mimic enzymes to combat oxidative stress-related diseases. This promising research by Tengfei Liu, Bowen Xiao, Fei Xiang, Jianglin Tan, Zhuo Chen, Xiaorong Zhang, Chengzhou Wu, Zhengwei Mao, Gaoxing Luo, Xiaoyuan Chen, and Jun Deng sheds light on their remarkable ROS scavenging abilities and their implications for treating acute injuries and enhancing wound healing.

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Abstract

Oxidative stress contributes to various inflammatory diseases, but clinical treatments remain limited. This study introduces ultrasmall Cu₅₄₀ nanoparticles (Cu₅₄₀ USNPs) as enzyme-mimicking nanozymes with broad-spectrum reactive oxygen species (ROS) scavenging ability. Cu₅₄₀ USNPs exhibit catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking properties, demonstrating cytoprotective effects at low dosages and improving outcomes in acute kidney injury, acute liver injury, and wound healing. Their ultrasmall size allows for rapid renal clearance and biocompatibility. The results highlight the potential of Cu₅₄₀ USNPs for clinical treatment of ROS-related diseases.

Publisher

Nature Communications

Published On

Jul 21, 2020

Authors

Tengfei Liu, Bowen Xiao, Fei Xiang, Jianglin Tan, Zhuo Chen, Xiaorong Zhang, Chengzhou Wu, Zhengwei Mao, Gaoxing Luo, Xiaoyuan Chen, Jun Deng

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