Biology

A novel satiety sensor detects circulating glucose and suppresses food consumption via insulin-producing cells in Drosophila

W. Qi, G. Wang, et al.

This groundbreaking research by Wei Qi, Gaohang Wang, and Liming Wang delves into the neural mechanisms behind satiety sensing in Drosophila. The discovery of Drosophila tachykinin and its receptor, which suppress feeding by targeting insulin-producing cells, offers exciting insights into how nutrition influences behavior and energy balance.

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Abstract

This research investigated the neural mechanism of satiety sensing in Drosophila. Through RNAi screening, Drosophila tachykinin (DTK) and its receptor TAKR99D were identified as feeding suppressors. Two pairs of DTK neurons in the fly brain, activated by elevated hemolymph D-glucose, suppress feeding by targeting insulin-producing cells (IPCs) via TAKR99D+ neurons. This DTK-TAKR99D-IPC circuitry is rapidly activated during food ingestion, effectively regulating feeding behavior. This discovery reveals a novel satiety sensor in Drosophila that detects specific circulating nutrients and modulates feeding, providing insights into the neural regulation of energy homeostasis.

Publisher

Cell Research

Published On

Dec 03, 2020

Authors

Wei Qi, Gaohang Wang, Liming Wang

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