This study investigated the expression of pyroptosis-related genes in ovarian cancer (OC) and their correlation with prognosis. Thirty-one differentially expressed genes (DEGs) were identified between OC and normal ovarian tissues. A 7-gene signature was constructed using LASSO Cox regression analysis from the TCGA cohort, effectively classifying patients into low- and high-risk groups with significantly different survival rates (P < 0.001). This signature was validated in a GEO cohort (P = 0.014). The risk score was an independent predictor of OC prognosis. GO and KEGG analyses revealed enrichment of immune-related genes, with the high-risk group showing decreased immune status. The findings suggest that pyroptosis-related genes play crucial roles in tumor immunity and prognosis prediction in OC.

Ying Ye, Qinjin Dai, Hongbo Qi