Medicine and Health

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Y. Ye, Q. Dai, et al.

This study by Ying Ye, Qinjin Dai, and Hongbo Qi reveals crucial insights into the role of pyroptosis-related genes in ovarian cancer. A 7-gene signature was linked to patient survival, distinguishing low- and high-risk groups with significant differences in outcomes. The research highlights the importance of tumor immunity and prognosis prediction in OC, emphasizing how these genes correlate with patient survival rates.

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Abstract

This study investigated the expression of pyroptosis-related genes in ovarian cancer (OC) and their correlation with prognosis. Thirty-one differentially expressed genes (DEGs) were identified between OC and normal ovarian tissues. A 7-gene signature was constructed using LASSO Cox regression analysis from the TCGA cohort, effectively classifying patients into low- and high-risk groups with significantly different survival rates (P < 0.001). This signature was validated in a GEO cohort (P = 0.014). The risk score was an independent predictor of OC prognosis. GO and KEGG analyses revealed enrichment of immune-related genes, with the high-risk group showing decreased immune status. The findings suggest that pyroptosis-related genes play crucial roles in tumor immunity and prognosis prediction in OC.

Publisher

Cell Death Discovery

Published On

Apr 07, 2021

Authors

Ying Ye, Qinjin Dai, Hongbo Qi

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