Medicine and Health

A new approach for investigating the relative contribution of basal glucose and postprandial glucose to HbA1c

J. Ma, H. He, et al.

This groundbreaking study by Jing Ma and colleagues explores a new methodology for assessing how both basal glucose and postprandial glucose influence glycated haemoglobin levels. By using Continuous Glucose Monitoring Systems on 490 participants, the research reveals crucial insights on the progression from impaired glucose tolerance to diabetes, highlighting significantly different contributions of postprandial glucose across various stages of glucose regulation.

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Playback language: English

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Abstract

This study aimed to develop an accurate method for evaluating the relative contributions of basal glucose (BG) and postprandial glucose (PPG) to glycated haemoglobin (HbA1c) using a Continuous Glucose Monitoring System (CGMS). 490 subjects were divided into normal glucose tolerance (NGT), impaired glucose tolerance (IGT), newly-diagnosed type 2 diabetes (NDDM), and drug-treated type 2 diabetes (T2DM) groups. Relative contributions of PPG to HbA1c were calculated using baseline values of 6.1 mmol/L, 5.6 mmol/L, and the 24-h glucose curve of the NGT group. Results showed that the relative contribution of PPG to HbA1c decreased progressively from IGT to T2DM. Using the 24-h NGT glucose curve as a baseline provided the most accurate results; using 6.1 mmol/L overestimated PPG contribution, while 5.6 mmol/L offered a reasonable alternative when the NGT curve was unavailable.

Publisher

Nutrition and Diabetes

Published On

Jun 04, 2021

Authors

Jing Ma, Hua He, Xiaojie Yang, Dawei Chen, Cuixia Tan, Li Zhong, Qiling Du, Xiaohua Wu, Yunyi Gao, Guanjian Liu, Chun Wang, Xingwu Ran

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