This study aimed to develop an accurate method for evaluating the relative contributions of basal glucose (BG) and postprandial glucose (PPG) to glycated haemoglobin (HbA1c) using a Continuous Glucose Monitoring System (CGMS). 490 subjects were divided into normal glucose tolerance (NGT), impaired glucose tolerance (IGT), newly-diagnosed type 2 diabetes (NDDM), and drug-treated type 2 diabetes (T2DM) groups. Relative contributions of PPG to HbA1c were calculated using baseline values of 6.1 mmol/L, 5.6 mmol/L, and the 24-h glucose curve of the NGT group. Results showed that the relative contribution of PPG to HbA1c decreased progressively from IGT to T2DM. Using the 24-h NGT glucose curve as a baseline provided the most accurate results; using 6.1 mmol/L overestimated PPG contribution, while 5.6 mmol/L offered a reasonable alternative when the NGT curve was unavailable.
Publisher
Nutrition and Diabetes
Published On
Jun 04, 2021
Authors
Jing Ma, Hua He, Xiaojie Yang, Dawei Chen, Cuixia Tan, Li Zhong, Qiling Du, Xiaohua Wu, Yunyi Gao, Guanjian Liu, Chun Wang, Xingwu Ran
Tags
glycated haemoglobin
basal glucose
postprandial glucose
Continuous Glucose Monitoring
type 2 diabetes
impaired glucose tolerance
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