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A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responses

Medicine and Health

A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responses

C. A. Arbeláez, J. Estrada, et al.

This groundbreaking study by Carlos A. Arbeláez and team explores a novel nanoparticle vaccine that targets neoantigens to boost antitumor T cell responses. Utilizing KRAS G12D mutations, they demonstrated that the innovative SLP-Lpx approach outperforms conventional vaccines in tumor suppression, especially when combined with checkpoint inhibitors.

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