Engineering and Technology

A Modular Plug-and-Play System for Highly Parallel Microfluidic Cell Culture

Vollertsen

Discover a groundbreaking modular plug-and-play system for microfluidic cell culture developed by Vollertsen and team, overcoming the challenges of traditional monolithic chips! This innovative approach utilizes a fluidic circuit board to interconnect microfluidic building blocks, showcasing impressive capabilities in culturing human umbilical vein endothelial cells while enabling flexible design modifications.

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Playback language: English

Index

Abstract

This paper presents a modular plug-and-play system for microfluidic cell culture, addressing the challenges of highly integrated monolithic chips. The system uses a fluidic circuit board (FCB) to connect multiple microfluidic building blocks (MFBBs) in a standardized fashion, enabling flexible alterations to the design and parallel operation. The authors developed an FCB with an active function (an MFBB enabler) to control mLSI MFBBs selectively, showcasing its versatility by controlling both mLSI and dosing MFBBs simultaneously. The system’s ability to culture human umbilical vein endothelial cells (HUVECs) is demonstrated.

Publisher

Microsystems & Nanoengineering

Published On

Authors

Vollertsen

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