Medicine and Health

A mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma

C. Paterson, I. Bozic, et al.

Explore the groundbreaking mechanistic mathematical model of vestibular schwannoma (VS) initiation and its potential for malignant transformation, crafted by a team of experts including Chay Paterson, Ivana Bozic, Miriam J. Smith, Xanthe Hoad, and D. Gareth R. Evans. This research offers new insights into mutation rates and the risks associated with radiotherapy.

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Abstract

This paper presents a mechanistic mathematical model of vestibular schwannoma (VS) initiation and malignant transformation. The model incorporates specific genes and mechanisms, using incidence data and empirical frequencies of pathogenic variants and loss of heterozygosity (LOH) to estimate parameters. New estimates for the base-pair mutation rate and LOH rate in Schwann cells are derived. The model is extended to estimate the risk of spontaneous and radiation-induced malignant transformation, concluding that radiotherapy likely poses a negligible excess risk of malignancy for sporadic VS, except possibly for rapidly growing tumors.

Publisher

British Journal of Cancer

Published On

Sep 12, 2022

Authors

Chay Paterson, Ivana Bozic, Miriam J. Smith, Xanthe Hoad, D. Gareth R. Evans

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