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A large screen identifies beta-lactam antibiotics which can be repurposed to target the syphilis agent

Medicine and Health

A large screen identifies beta-lactam antibiotics which can be repurposed to target the syphilis agent

K. A. Hayes, J. M. Dressler, et al.

Syphilis is making a comeback and traditional treatments might not be enough! This study, conducted by Kathryn A. Hayes, Jules M. Dressler, Steven J. Norris, Diane G. Edmondson, and Brandon L. Jutras, explores the efficacy of nearly 100 β-lactams against *Treponema pallidum*, revealing several promising alternatives to benzathine penicillin G.

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Playback language: English
Abstract
Syphilis, a re-emerging sexually transmitted infection, is primarily treated with benzathine penicillin G. Due to supply shortages and potential resistance, this study screened nearly 100 β-lactams against *Treponema pallidum* using a novel in vitro culture system. Several β-lactams, including some currently used antibiotics and synthetic derivatives, showed efficacy comparable to or exceeding benzathine penicillin G, offering potential new treatment options for syphilis.
Publisher
npj Antimicrobials & Resistance
Published On
Jun 01, 2023
Authors
Kathryn A. Hayes, Jules M. Dressler, Steven J. Norris, Diane G. Edmondson, Brandon L. Jutras
Tags
Syphilis
Treponema pallidum
β-lactams
benzathine penicillin G
antibiotics
treatment options

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