Medicine and Health

Effect of inulin on breath hydrogen, postprandial glycemia, gut hormone release, and appetite perception in RYGB patients: a prospective, randomized, cross-over pilot study

R. E. Steinert, M. Mueller, et al.

Discover how large intestinal fermentation of dietary fiber may enhance the effects of Roux-en-Y gastric bypass surgery. This groundbreaking study reveals insights from R. E. Steinert and colleagues into appetite suppression and glucose regulation post-surgery. Find out what happens when patients are given inulin or maltodextrin!

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Playback language: English

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Abstract

This study investigated whether large intestinal fermentation of dietary fiber contributes to the efficacy of Roux-en-Y gastric bypass (RYGB) surgery. Eight RYGB patients received either inulin or maltodextrin with orange juice, and parameters like breath hydrogen, plasma SCFAs, gut hormones, insulin, glucose, and appetite were assessed. Surgery increased GLP-1 and PYY secretion, lowered blood glucose and insulin, and reduced appetite. Inulin's effect on breath hydrogen was accelerated after surgery, but plasma SCFAs, GLP-1, and PYY were unaffected. Inulin potentiated surgery's glucose-lowering and appetite-suppressive effects, with appetite suppression correlating with early breath hydrogen.

Publisher

Nutrition & Diabetes

Published On

Mar 06, 2024

Authors

R. E. Steinert, M. Mueller, M. Serra, S. Lehner-Sigrist, G. Frost, D. Gero, P. A. Gerber, M. Bueter

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