Chemistry

A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy

R. Lincoln, M. L. Bossi, et al.

This groundbreaking research introduces PaX dyes, innovative caging-group-free photoactivatable fluorophores that transition into highly fluorescent pyronine dyes upon light activation. Conducted by Richard Lincoln, Mariano L. Bossi, Michael Remmel, Elisa D’Este, Alexey N. Butkevich, and Stefan W. Hell, this method offers a versatile and efficient approach to microscopy, enabling detailed imaging for both fixed and live cells across various techniques.

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