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A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

Agriculture

A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

J. Haywood, K. J. Breese, et al.

This innovative research highlights the potential of HMG-CoA reductase as a novel herbicide target. By unveiling the crystal structure of Arabidopsis thaliana HMGR, the authors demonstrate how a wider active site can pave the way for the creation of species-specific HMGR inhibitors, offering a fresh avenue in the fight against herbicide resistance. The study was conducted by Joel Haywood, Karen J. Breese, Jingjing Zhang, Mark T. Waters, Charles S. Bond, Keith A. Stubbs, and Joshua S. Mylne.

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