Agriculture

A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

J. Haywood, K. J. Breese, et al.

This innovative research highlights the potential of HMG-CoA reductase as a novel herbicide target. By unveiling the crystal structure of Arabidopsis thaliana HMGR, the authors demonstrate how a wider active site can pave the way for the creation of species-specific HMGR inhibitors, offering a fresh avenue in the fight against herbicide resistance. The study was conducted by Joel Haywood, Karen J. Breese, Jingjing Zhang, Mark T. Waters, Charles S. Bond, Keith A. Stubbs, and Joshua S. Mylne.

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Abstract

The rise of herbicide resistance necessitates new herbicidal modes of action. This paper investigates HMG-CoA reductase (HMGR), a rate-limiting enzyme in the mevalonate pathway, as a potential herbicide target. The authors present the crystal structure of Arabidopsis thaliana HMGR (AtHMG1), revealing a wider active site than in other species. This allows for the rational design of species-specific HMGR inhibitors. A tolerance trait is also developed by analyzing fungal gene clusters. The results suggest HMGR is a viable herbicide target, with the potential for modification to confer tolerance.

Publisher

Nature Communications

Published On

Sep 22, 2022

Authors

Joel Haywood, Karen J. Breese, Jingjing Zhang, Mark T. Waters, Charles S. Bond, Keith A. Stubbs, Joshua S. Mylne

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