This research optimized the RL-QN15 peptide to create CYRL-QN15, a cyclic heptapeptide with improved efficacy in treating skin wounds. A Zn²⁺-crosslinked sodium alginate (ZA) hydrogel containing hollow polydopamine (HPDA) nanoparticles loaded with CYRL-QN15 (HPDA/CYRL-QN15/ZA hydrogel) was developed. This hydrogel accelerated skin cell proliferation, migration, and tube formation, regulated cytokine secretion from macrophages, scavenged free radicals, and reduced reactive oxygen species. In diabetic mice, the hydrogel significantly accelerated full-thickness skin wound healing by promoting M2 macrophage polarization, re-epithelialization, granulation tissue formation, collagen deposition, and angiogenesis. The hydrogel also showed efficacy in treating diabetic skin ulcers in patients. The HPDA/CYRL-QN15/ZA hydrogel offers a novel therapeutic strategy for chronic skin wound healing.
Publisher
NPG Asia Materials
Published On
Authors
Zhe Fu, Huiling Sun, Yutong Wu, Chao Li, Yinglei Wang, Yixiang Liu, Yilin Li, Junxu Nie, Dandan Sun, Yingxuan Zhang, Naixin Liu, Kun Guo, Saige Yin, Qiuyue Jia, Ying Yang, Li He, Ying Wang, Xinwang Yang
Tags
skin wound healing
CYRL-QN15
hydrogel
diabetic ulcers
macrophage polarization
collagen deposition
reactive oxygen species
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