A comprehensive synthetic library of poly-N-acetyl glucosamines | ResearchBunny

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Abstract

This study synthesized a comprehensive library of 32 PNAG pentasaccharides to identify PNAG sequences with specific free amine patterns as epitopes for vaccines against *Staphylococcus aureus*. Active and passive vaccination using a conjugate of the discovered PNAG epitope with mutant bacteriophage Qβ provided near-complete protection against *S. aureus* infections in mice, including MRSA. This library is a valuable tool for next-generation vaccine design.

Publisher

Nature Communications

Published On

Apr 24, 2024

Authors

Zibin Tan, Weizhun Yang, Nicholas A. O’Brien, Xingling Pan, Sherif Ramadan, Terence Marsh, Neal Hammer, Colette Cywes-Bentley, Mariana Vinacur, Gerald B. Pier, Jeffrey C. Gildersleeve, Xuefei Huang

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