Medicine and Health

A 3D-printed magnetic digital microfluidic diagnostic platform for rapid colorimetric sensing of carbapenemase-producing Enterobacteriaceae

P. Kanitthamniyom, P. Y. Hon, et al.

Discover MDM Carba, an innovative magnetic digital microfluidic platform for the rapid identification of drug-resistant carbapenemase-producing Enterobacteriaceae. Conducted by a team of researchers including Pojchanun Kanitthamniyom and Pei Yun Hon, this groundbreaking study showcases an automated and efficient method that enhances diagnostics in challenging clinical environments.

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Abstract

Carbapenemase-producing Enterobacteriaceae (CPE) are drug-resistant pathogens posing a critical threat. This paper presents MDM Carba, a magnetic digital microfluidic (MDM) platform for rapid CPE identification by measuring carbapenem hydrolysis. MDM Carba uses droplets as reaction chambers, manipulated by magnetic force, enabling automation and reduced reagent use. Testing 27 isolates, MDM Carba showed sensitivity and specificity comparable to the Carba NP test, offering potential for faster diagnosis and improved clinical outcomes, particularly in resource-limited settings.

Publisher

Microsystems & Nanoengineering

Published On

Jan 01, 2021

Authors

Pojchanun Kanitthamniyom, Pei Yun Hon, Aiwu Zhou, Mohammad Yazid Abdad, Zhi Yun Leow, Nurhidayah Binte Mohamed Yazid, Vanessa Lim Wei Xun, Shawn Vasoo, Yi Zhang

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