This cross-sectional study investigated the relationship between vitamin D metabolites and the gut microbiome in 567 older men. Serum vitamin D metabolites were quantified using LC-MSMS, and stool sub-Operational Taxonomic Units (sOTUs) were defined from 16S rRNA gene sequencing data. Higher levels of the active vitamin D metabolite, 1,25(OH)₂D, and higher vitamin D activation ratios were associated with greater gut microbiome α-diversity and the presence of butyrate-producing bacteria, indicating a potential link between vitamin D metabolism and gut microbial health.
Publisher
Nature Communications
Published On
Nov 26, 2020
Authors
Robert L. Thomas, Lingjing Jiang, John S. Adams, Zhenjiang Zech Xu, Jian Shen, Stefan Janssen, Gail Ackermann, Dirk Vanderschueren, Steven Pauwels, Rob Knight, Eric S. Orwoll, Deborah M. Kado
Tags
vitamin D
gut microbiome
α-diversity
butyrate-producing bacteria
older men
vitamin D metabolites
16S rRNA gene sequencing
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