Medicine and Health

Vitamin D metabolites and the gut microbiome in older men

R. L. Thomas, L. Jiang, et al.

This study reveals a fascinating connection between vitamin D metabolites and the gut microbiome in older men, indicating that higher levels of the active vitamin D metabolite, 1,25(OH)₂D, could enhance gut health by promoting microbial diversity and butyrate-producing bacteria. Conducted by an expert team including Robert L. Thomas and others from various prestigious institutions, the findings suggest a compelling link between vitamin D metabolism and gut health.

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Abstract

This cross-sectional study investigated the relationship between vitamin D metabolites and the gut microbiome in 567 older men. Serum vitamin D metabolites were quantified using LC-MSMS, and stool sub-Operational Taxonomic Units (sOTUs) were defined from 16S rRNA gene sequencing data. Higher levels of the active vitamin D metabolite, 1,25(OH)₂D, and higher vitamin D activation ratios were associated with greater gut microbiome α-diversity and the presence of butyrate-producing bacteria, indicating a potential link between vitamin D metabolism and gut microbial health.

Publisher

Nature Communications

Published On

Nov 26, 2020

Authors

Robert L. Thomas, Lingjing Jiang, John S. Adams, Zhenjiang Zech Xu, Jian Shen, Stefan Janssen, Gail Ackermann, Dirk Vanderschueren, Steven Pauwels, Rob Knight, Eric S. Orwoll, Deborah M. Kado

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