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Vaccination of cattle with the *Babesia bovis* sexual-stage protein HAP2 abrogates parasite transmission by *Rhipicephalus microplus* ticks

Veterinary Science

Vaccination of cattle with the *Babesia bovis* sexual-stage protein HAP2 abrogates parasite transmission by *Rhipicephalus microplus* ticks

M. G. Silva, R. G. Bastos, et al.

This groundbreaking study explores the potential of recombinant HAP2 as a transmission-blocking vaccine against *Babesia bovis*. Vaccinated calves showcased a remarkable immune response, preventing engorged ticks from transmitting the parasite, unlike their unvaccinated counterparts. Conducted by esteemed researchers Marta G. Silva, Reginaldo G. Bastos, Jacob M. Laughery, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, and Carlos E. Suarez, this work highlights a promising approach to combatting this significant concern in veterinary medicine.

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Playback language: English
Abstract
This study investigated the potential of recombinant HAP2 (rHAP2), a *Babesia bovis* sexual-stage protein, as a transmission-blocking vaccine (TBV). Calves vaccinated with rHAP2 developed HAP2-specific antibodies. Following infection with *B. bovis*, engorged ticks from vaccinated calves produced larvae that failed to transmit the parasite to naive calves, unlike larvae from control calves. This demonstrates rHAP2's potential as a TBV candidate against *B. bovis*.
Publisher
npj Vaccines
Published On
Sep 27, 2023
Authors
Marta G. Silva, Reginaldo G. Bastos, Jacob M. Laughery, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, Carlos E. Suarez
Tags
recombinant HAP2
Babesia bovis
transmission-blocking vaccine
vaccinated calves
immune response
engorged ticks
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