Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences

This study investigated urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences (PLEs) in adolescents. A population-based subsample of the Tokyo Teen Cohort Study (345 participants) underwent PLE assessments at ages 13 and 14. Fifteen adolescents with persistent PLEs and 15 age- and sex-matched adolescents with remitted PLEs were compared for urinary exosomal miRNA expression. Six differentially expressed microRNAs (hsa-miR-486-5p, hsa-miR-199a-3p, hsa-miR-144-5p, hsa-miR-451a, hsa-miR-143-3p, and hsa-miR-142-3p) were identified. A logistic regression model using these miRNAs showed high accuracy (AUC 0.860) in predicting persistent PLEs, suggesting their potential as novel biomarkers for psychiatric disorders.

Yasufumi Tomita, Kazuhiro Suzuki, Syudo Yamasaki, Kazuya Toriumi, Mitsuhiro Miyashita, Shuntaro Ando, Kaori Endo, Akane Yoshikawa, Koichi Tabata, Satoshi Usami, Mariko Hiraiwa-Hasegawa, Masanari Itokawa, Hideya Kawaji, Kiyoto Kasai, Atsushi Nishida, Makoto Arai