Medicine and Health

Glioblastoma biomarkers in urinary extracellular vesicles reveal the potential for a ‘liquid gold’ biopsy

S. M. Hallal, Ä. Tüzes, et al.

This groundbreaking study by Susannah M. Hallal and colleagues unveils the potential of urinary extracellular vesicles as a non-invasive liquid biopsy for glioblastoma. By identifying glioblastoma-specific proteomic signatures, this research opens new avenues for monitoring tumor burden and recurrence, promising a revolution in patient care.

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Abstract

This study explored the potential of urinary extracellular vesicles (EVs) as a non-invasive liquid biopsy for glioblastoma. Urinary EVs from glioblastoma patients and healthy controls were analyzed using high-resolution mass spectrometry. Glioblastoma-specific proteomic signatures were identified, revealing potential biomarkers for tumor burden and recurrence. These findings suggest urinary EVs could provide a valuable tool for monitoring glioblastoma.

Publisher

British Journal of Cancer

Published On

Jan 11, 2024

Authors

Susannah M. Hallal, Ägota Tüzes, Liam A. Sida, Elissa Xian, Daniel Madani, Krishna Muralidharan, Brindha Shivalingam, Michael E. Buckland, Laevinya Satgunaseelan, Kimberly L. Alexander

DOI

https://doi.org/10.1038/s41416-023-02548-9

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