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Unlocking the potentials of cyanobacterial photosynthesis for directly converting carbon dioxide into glucose

Biology

Unlocking the potentials of cyanobacterial photosynthesis for directly converting carbon dioxide into glucose

S. Zhang, J. Sun, et al.

Discover how researchers Shanshan Zhang, Jiahui Sun, Dandan Feng, Huili Sun, Jinyu Cui, Xuexia Zeng, Yannan Wu, Guodong Luan, and Xuefeng Lu have unlocked the potential of Synechococcus elongatus PCC 7942 for photosynthetic glucose production. By engineering metabolic pathways, they achieved remarkable glucose accumulation and secretion, showcasing the innovative capabilities of cyanobacteria.

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Playback language: English
Abstract
This research explores the potential of Synechococcus elongatus PCC 7942 for photosynthetic glucose production. By knocking out two glucokinase genes, the researchers prevented native glucokinase activity, leading to glucose accumulation and secretion. Without additional heterologous genes, a glucose secretion of 1.5 g/L was achieved, further increased to 5 g/L through metabolic and cultivation engineering. This highlights cyanobacterial metabolic plasticity and its potential for direct photosynthetic glucose production.
Publisher
Nature Communications
Published On
Jun 09, 2023
Authors
Shanshan Zhang, Jiahui Sun, Dandan Feng, Huili Sun, Jinyu Cui, Xuexia Zeng, Yannan Wu, Guodong Luan, Xuefeng Lu
Tags
Synechococcus elongatus
photosynthetic glucose production
glucokinase gene knockout
metabolic engineering
cyanobacterial plasticity
glucose secretion

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