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Abstract
This research explores the potential of Synechococcus elongatus PCC 7942 for photosynthetic glucose production. By knocking out two glucokinase genes, the researchers prevented native glucokinase activity, leading to glucose accumulation and secretion. Without additional heterologous genes, a glucose secretion of 1.5 g/L was achieved, further increased to 5 g/L through metabolic and cultivation engineering. This highlights cyanobacterial metabolic plasticity and its potential for direct photosynthetic glucose production.
Publisher
Nature Communications
Published On
Jun 09, 2023
Authors
Shanshan Zhang, Jiahui Sun, Dandan Feng, Huili Sun, Jinyu Cui, Xuexia Zeng, Yannan Wu, Guodong Luan, Xuefeng Lu
Tags
Synechococcus elongatus
photosynthetic glucose production
glucokinase gene knockout
metabolic engineering
cyanobacterial plasticity
glucose secretion

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