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Understanding sex differences in long-term outcomes after a first episode of psychosis

Psychology

Understanding sex differences in long-term outcomes after a first episode of psychosis

R. Ayesa-arriola, V. O. D. L. Foz, et al.

This compelling research investigates the long-term sex differences in outcomes among first-episode psychosis patients, uncovering that women initially outperform men but show diminishing differences over time, with intriguing implications for treatment. This study was conducted by Rosa Ayesa-Arriola, Víctor Ortíz-García de la Foz, Esther Setién-Suero, María Luz Ramírez-Bonilla, Paula Suárez-Pinilla, Jacqueline Mayoral-van Son, Javier Vázquez-Bourgon, María Juncal-Ruiz, Marcos Gómez-Revuelta, Diana Tordesillas-Gutiérrez, and Benedicto Crespo-Facorro.

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Playback language: English
Abstract
This study investigated long-term sex differences in outcomes among 209 first-episode psychosis (FEP) patients (95 females, 114 males) reassessed 8-16 years after their first contact with an Early Intervention Service (EIS). Women showed better outcomes in the first 3 years, including better response to lower antipsychotic doses and higher recovery rates. However, at the 10-year follow-up, differences diminished, except for negative symptoms, suggesting that initial advantages for women may be related to premorbid factors and that increased antipsychotic dosage after EIS discharge may affect long-term outcomes for both sexes.
Publisher
npj Schizophrenia
Published On
Nov 20, 2020
Authors
Rosa Ayesa-Arriola, Víctor Ortíz-García de la Foz, Esther Setién-Suero, María Luz Ramírez-Bonilla, Paula Suárez-Pinilla, Jacqueline Mayoral-van Son, Javier Vázquez-Bourgon, María Juncal-Ruiz, Marcos Gómez-Revuelta, Diana Tordesillas-Gutiérrez, Benedicto Crespo-Facorro
Tags
first-episode psychosis
sex differences
treatment outcomes
antipsychotic dosage
long-term recovery
negative symptoms
Early Intervention Service

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