Medicine and Health

Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study

A. Dey, K. Dempster, et al.

This groundbreaking study by Avyarthana Dey and colleagues explores the brain regions linked to conceptual disorganization in first-episode psychosis using advanced 7T resting-state fMRI. The researchers discovered reduced centrality in the right superior temporal gyrus and a compensatory cortical reorganization in the medial superior parietal region, especially in patients with higher CD scores, highlighting intriguing neurobiological changes in untreated individuals.

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Abstract

This study investigated brain regions associated with the severity of conceptual disorganization (CD) in first-episode psychosis (FEP) using 7T resting-state fMRI. Compared to healthy controls, FEPs showed reduced centrality in a right superior temporal gyrus (rSTG) cluster. Patients with high CD scores exhibited increased centrality in a medial superior parietal (mSPL) cluster, strongly correlated with CD but not other symptoms. The findings suggest cortical reorganization, potentially compensatory, in untreated FEP.

Publisher

npj Schizophrenia

Published On

Jan 26, 2021

Authors

Avyarthana Dey, Kara Dempster, Michael MacKinley, Peter Jeon, Tushar Das, Ali Khan, Joe Gati, Lena Palaniyappan

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