Conceptual disorganization and redistribution of resting-state | ResearchBunny

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Abstract

This study investigated brain regions associated with the severity of conceptual disorganization (CD) in first-episode psychosis (FEP) using 7T resting-state fMRI. Compared to healthy controls, FEPs showed reduced centrality in a right superior temporal gyrus (rSTG) cluster. Patients with high CD scores exhibited increased centrality in a medial superior parietal (mSPL) cluster, strongly correlated with CD but not other symptoms. The findings suggest cortical reorganization, potentially compensatory, in untreated FEP.

Publisher

npj Schizophrenia

Published On

Jan 26, 2021

Authors

Avyarthana Dey, Kara Dempster, Michael MacKinley, Peter Jeon, Tushar Das, Ali Khan, Joe Gati, Lena Palaniyappan

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