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Abstract
This study investigates the association between type 2 diabetes (T2D) and its genetic susceptibility with COVID-19 severity and mortality using data from 459,119 individuals in the UK Biobank. The researchers found a significant association between T2D or T2D polygenic risk scores (PRS) and COVID-19 severity, highlighting the efficacy of vaccination and the role of T2D-related genetics in severe COVID-19. Individuals with T2D or high T2D PRS had significantly increased mortality rates, which were 2 to 7 times higher for SARS-CoV-2-infected patients depending on the infection time. These findings emphasize the potential of T2D PRS in predicting COVID-19 severity and mortality.
Publisher
Communications Biology
Published On
Jan 21, 2024
Authors
Ayeon Lee, Jieun Seo, Seunghwan Park, Youngkwang Cho, Gaeun Kim, Jun Li, Liming Liang, Taesung Park, Wonil Chung
Tags
COVID-19
type 2 diabetes
genetic susceptibility
mortality rates
polygenic risk scores
vaccination efficacy
UK Biobank

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