Medicine and Health

Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank

A. Lee, J. Seo, et al.

This groundbreaking study by Ayeon Lee, Jieun Seo, Seunghwan Park, Youngkwang Cho, Gaeun Kim, Jun Li, Liming Liang, Taesung Park, and Wonil Chung explores the relationship between type 2 diabetes and COVID-19 severity. By analyzing data from 459,119 individuals, significant links were found indicating that those with type 2 diabetes face drastically increased mortality rates from COVID-19. This research sheds light on the vital role of genetic factors in understanding and predicting COVID-19 outcomes.

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Abstract

This study investigates the association between type 2 diabetes (T2D) and its genetic susceptibility with COVID-19 severity and mortality using data from 459,119 individuals in the UK Biobank. The researchers found a significant association between T2D or T2D polygenic risk scores (PRS) and COVID-19 severity, highlighting the efficacy of vaccination and the role of T2D-related genetics in severe COVID-19. Individuals with T2D or high T2D PRS had significantly increased mortality rates, which were 2 to 7 times higher for SARS-CoV-2-infected patients depending on the infection time. These findings emphasize the potential of T2D PRS in predicting COVID-19 severity and mortality.

Publisher

Communications Biology

Published On

Jan 21, 2024

Authors

Ayeon Lee, Jieun Seo, Seunghwan Park, Youngkwang Cho, Gaeun Kim, Jun Li, Liming Liang, Taesung Park, Wonil Chung

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