Medicine and Health

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralizing antibodies in COVID-19 patients

C. M. Poh, G. Carissimo, et al.

This groundbreaking research identifies two immunodominant regions on the SARS-CoV-2 spike glycoprotein, revealing one region as SARS-CoV-2 specific near the receptor-binding domain and another as a potential pan-SARS target. Conducted by a team of experts, this study enhances our understanding of antibody-mediated neutralization, paving the way for improved therapies and vaccines.

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Abstract

This study identifies two IgG immunodominant regions on the SARS-CoV-2 spike glycoprotein recognized by sera from COVID-19 convalescent patients. One region is SARS-CoV-2 specific and near the receptor-binding domain; the other, located at the fusion peptide, may be a pan-SARS target. Antibody depletion assays show that antibodies targeting these regions significantly enhance neutralization capacities, providing insights for therapeutic and vaccine design.

Publisher

Nature Communications

Published On

Oct 26, 2020

Authors

Chek Meng Poh, Guillaume Carissimo, Bei Wang, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Rhonda Sin-Ling Chee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Wen-Hsin Lee, Anthony Torres-Ruesta, Yee-Sin Leo, Mark I-Cheng Chen, Seow-Yen Tan, Louis Yi Ann Chai, Shirin Kalimuddin, Shirley Seek Geh Kheng, Siew-Yee Thien, Barnaby Edward Young, David C. Lye, Brendon John Hanson, Cheng-I Wang, Laurent Renia, Lisa F. P. Ng

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