This paper reports the design and validation of a turn-on chemiluminescence probe, ADLumin-1, for amyloid beta (Aβ) species. The probe efficiently crosses the blood-brain barrier and provides excellent contrast for Aβ plaques and cerebral amyloid angiopathy in vivo. Signal amplification is further achieved using chemiluminescence resonance energy transfer (DAS-CRET) with two non-conjugated probes. The study suggests this strategy could be extended to other aggregating-prone proteins.
Publisher
NATURE COMMUNICATIONS
Published On
Aug 13, 2020
Authors
Jing Yang, Wei Yin, Richard Van, Keyi Yin, Peng Wang, Chao Zheng, Biyue Zhu, Kathleen Ran, Can Zhang, Mohanraja Kumar, Yihan Shao, Chongzhao Ran
Tags
chemiluminescence
Aβ species
blood-brain barrier
signal amplification
neurodegenerative diseases
diagnostic probe
imaging technology
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