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Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma

Medicine and Health

Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma

S. Wang, M. Du, et al.

This study unveils intriguing evolutionary trajectories in early lung adenocarcinoma (LUAD), identifying distinct variant patterns in pre-invasive and invasive components. The research reveals how EGFR mutations may decrease post-invasiveness, possibly linked to B cell infiltration. Discover the insights from this pioneering research conducted by Siwei Wang and colleagues.

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Playback language: English
Abstract
The evolutionary trajectories of early lung adenocarcinoma (LUAD) have not been fully elucidated. This study micro-dissected malignant pulmonary nodules (MPNs) into paired pre-invasive and invasive components for panel-genome sequencing, identifying three evolutionary trajectories. Two trajectories (EM2 and EM3) showed private variants in pre-invasive and invasive components, respectively, while one (EM1) showed no common driver events. EGFR mutations showed decreased abundance post-invasiveness, potentially linked to B cell infiltration. EGFR mutations influenced selective pressure and prognosis. These findings enhance understanding of LUAD invasiveness.
Publisher
Nature Communications
Published On
Nov 27, 2020
Authors
Siwei Wang, Mulong Du, Jingyuan Zhang, Weizhang Xu, Qianyu Yuan, Ming Li, Jie Wang, Hongyu Zhu, Yuzhou Wang, Cheng Wang, Yuhua Gong, Xiaonan Wang, Zhibin Hu, David C. Christiani, Lin Xu, Hongbing Shen, Rong Yin
Tags
lung adenocarcinoma
evolutionary trajectories
EGFR mutations
invasiveness
B cell infiltration

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