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TREM2 in Alzheimer's Disease: From Mechanisms to Therapeutic Strategies

Medicine and Health

TREM2 in Alzheimer's Disease: From Mechanisms to Therapeutic Strategies

M. Gratuze, C. E. Leyns, et al.

This review delves into the critical role of TREM2 in late-onset Alzheimer's disease, exploring its structure, signaling pathways, and potential as a therapeutic target. The insights gathered by authors Magali Gratuze, Cecilia E.G. Leyns, and David M. Holtzman may shed light on the complex interactions involving amyloid and tau pathologies.... show more
Abstract
Publisher
Molecular Neurodegeneration
Published On
Dec 20, 2018
Authors
Magali Gratuze, Cecilia E.G. Leyns, David M. Holtzman
Tags
TREM2
Alzheimer's disease
LOAD
apolipoprotein E
amyloid
tau
therapeutic target
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