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Translation initiation factor eIF1.2 promotes *Toxoplasma* stage conversion by regulating levels of key differentiation factors

Biology

Translation initiation factor eIF1.2 promotes *Toxoplasma* stage conversion by regulating levels of key differentiation factors

F. Wang, M. J. Holmes, et al.

Discover how eIF1.2, a translation initiation factor, plays a pivotal role in the differentiation of *Toxoplasma gondii*. This groundbreaking study reveals that mutations in eIF1.2 critically inhibit the formation of bradyzoite cysts, offering new insights into chronic toxoplasmosis and highlighting the translation regulation of crucial differentiation factors BFD1 and BFD2. This innovative research was conducted by Fengrong Wang, Michael J. Holmes, Hea Jin Hong, Pariyamon Thaprawat, Geetha Kannan, My-Hang Huynh, Tracey L. Schultz, M. Haley Licon, Sebastian Lourido, Wenzhao Dong, Jailson Brito Querido, William J. Sullivan Jr., Seán E. O'Leary, and Vern B. Carruthers.

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