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Towards Novel Biomimetic In Vitro Models of the Blood-Brain Barrier for Drug Permeability Evaluation

Engineering and Technology

Towards Novel Biomimetic In Vitro Models of the Blood-Brain Barrier for Drug Permeability Evaluation

I. Mármol, S. Abizanda-campo, et al.

Discover how recent advances in organ-on-chip brain models could revolutionize drug testing by accurately predicting drug permeability across the blood-brain barrier. This insightful review, conducted by Inés Mármol, Sara Abizanda-Campo, Jose M Ayuso, Ignacio Ochoa, and Sara Oliván, explores the potential of these innovative technologies in overcoming limitations of traditional drug evaluation methods.

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Playback language: English
Abstract
Current animal and in vitro cell-based models for studying brain-related pathologies and drug evaluation have limitations in reproducing the human blood-brain barrier's (BBB) architecture and physiology. This often leads to preclinical drug candidates failing in clinical trials due to poor BBB penetration. This review examines recent advances in organ-on-chip (OOC) BBB models, focusing on their potential to predict drug permeability. It highlights achievements and challenges in creating more biomimetic in vitro models using OOC technology, specifying the minimum requirements (cellular types, fluid flow, and tissue architecture) for a solid alternative to traditional in vitro models or animal models.
Publisher
Bioengineering
Published On
May 10, 2023
Authors
Inés Mármol, Sara Abizanda-Campo, Jose M Ayuso, Ignacio Ochoa, Sara Oliván
Tags
blood-brain barrier
organ-on-chip
drug permeability
biomimetic models
preclinical drug testing
in vitro models
brain-related pathologies

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