Psychology

Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Y. Joo, Y. Xue, et al.

Discover the pivotal role of Topoisomerase 3β (Top3β) in brain health and psychiatric disorders, as revealed by groundbreaking research from Yuyoung Joo and colleagues at the National Institute on Aging. Their studies show how Top3β knockout mice display behavioral phenotypes linked to cognitive impairments and disrupted neuronal activity. Unlock the secrets behind the neuronal functions that could lead to innovative treatments for mental health challenges.

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Index

Abstract

Topoisomerase 3β (Top3β) is a dual-activity topoisomerase linked to psychiatric disorders. Top3β knockout mice exhibited behavioral phenotypes related to psychiatric disorders and cognitive impairment, along with impairments in hippocampal neurogenesis and synaptic plasticity. Impaired global neuronal activity-dependent transcription was observed in response to fear conditioning stress, affecting genes with neuronal functions. This suggests Top3β is essential for normal brain function, with defective neuronal activity-dependent transcription being a potential mechanism for cognitive impairment and psychiatric disorders.

Publisher

Nature Communications

Published On

Jun 19, 2020

Authors

Yuyoung Joo, Yutong Xue, Yue Wang, Ross A. McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P. Mattson, Henriette van Praag, Alexei Sharov, Weidong Wang

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