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Abstract
Topoisomerase 3β (Top3β) is a dual-activity topoisomerase linked to psychiatric disorders. Top3β knockout mice exhibited behavioral phenotypes related to psychiatric disorders and cognitive impairment, along with impairments in hippocampal neurogenesis and synaptic plasticity. Impaired global neuronal activity-dependent transcription was observed in response to fear conditioning stress, affecting genes with neuronal functions. This suggests Top3β is essential for normal brain function, with defective neuronal activity-dependent transcription being a potential mechanism for cognitive impairment and psychiatric disorders.
Publisher
Nature Communications
Published On
Jun 19, 2020
Authors
Yuyoung Joo, Yutong Xue, Yue Wang, Ross A. McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P. Mattson, Henriette van Praag, Alexei Sharov, Weidong Wang
Tags
Topoisomerase 3β
psychiatric disorders
cognitive impairment
neurogenesis
neuronal activity
fear conditioning
transcription

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