Medicine and Health

To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

G. Corti, J. K. Kim, et al.

Explore the groundbreaking research conducted by renowned scientists including Giada Corti and Jang Keun Kim, as they unveil the intriguing link between spaceflight stressors and the risk of small-for-gestational-age infants. Discover how miRNA analysis and machine learning could pave the way for potential FDA-approved drug solutions.

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Playback language: English

Index

Abstract

This study investigates the potential impact of spaceflight on female reproductive health, specifically focusing on the risk of small-for-gestational-age (SGA) infants. The researchers hypothesize that space stressors could lead to lasting effects on female health, increasing SGA risk in future pregnancies. By analyzing miRNA expression data from SGA births and spaceflight experiments (both simulated and actual), they identify a shared miRNA signature. A machine learning approach then suggests potential FDA-approved drugs to mitigate these risks.

Publisher

Communications Biology

Published On

Oct 05, 2024

Authors

Giada Corti, Jang Keun Kim, Francisco J. Enguita, Joseph W. Guarnieri, Lawrence I. Grossman, Sylvain V. Costes, Matias Fuentealba, Ryan T. Scott, Andrea Magrini, Lauren M. Sanders, Kanhaiya Singh, Chandan K. Sen, Cassandra M. Juran, Amber M. Paul, David Furman, Jean Calleja-Agius, Christopher E. Mason, Diego Galeano, Massimo Bottini, Afshin Beheshti

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