Medicine and Health

The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer's Disease

L. Hritcu, K. Barber, et al.

Unravel the potential of Cardamonin, a phytochemical with remarkable antioxidant and anti-inflammatory effects, in combating Alzheimer's disease. Conducted by a team of researchers from Florida A&M University, this review highlights Cardamonin's ability to influence critical signaling molecules and its promising role in neuroprotection.

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Playback language: English

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Abstract

Neurodegenerative diseases (NDs) are characterized by progressive neuronal damage. Alzheimer's disease (AD), a prevalent ND, is driven by neuroinflammation and oxidative stress (OS). Cardamonin (CD), a phytochemical found in plants like *Alpinia katsumadai*, exhibits antioxidant and anti-inflammatory properties. This review explores CD's neuroprotective effects, focusing on its ability to modulate signaling molecules involved in AD pathogenesis, including transcription factors, cytokines, enzymes, and other proteins and genes. The review also examines CD's impact on miRNA levels and autophagy. Overall, the review suggests CD's potential as a therapeutic agent for AD prevention and treatment.

Publisher

Brain Sciences

Published On

Jan 14, 2023

Authors

Lucian Hritcu, Kimberly Barber, Patricia Mendonca, F A Soliman, K M F A S

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