BiologyNature Communications
The massed-spaced learning effect in non-neural human cells
N. V. Kukushkin, R. E. Carney, et al.
This study shows the classic massed–spaced memory effect in two non-neural, immortalized cell lines using a short-lived CREB-dependent luciferase reporter: four spaced pulses of forskolin or phorbol ester produced stronger, longer-lasting luciferase expression and sustained ERK/CREB activation, which was blocked by ERK or CREB inhibition. Research conducted by N. V. Kukushkin, R. E. Carney, T. Tabassum, and T. J. Carew.
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