Medicine and Health
The design and evaluation of hybrid controlled trials that leverage external data and randomization
S. Ventz, S. Khozin, et al.
This innovative research, conducted by a talented team including Steffen Ventz, Sean Khozin, and others, unveils a hybrid clinical trial design that melds external control datasets with randomization, optimizing treatment effect inference and addressing confounders in patient characteristics. Through simulations involving ES-SCLC and GBM studies, the study showcases the superiority of this approach over traditional trial methodologies.
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