logo
ResearchBunny Logo
Abstract
This study investigated the acute impact of the BNT162b2 COVID-19 vaccine on a human ex vivo model of severe eosinophilic asthma. Passively sensitized human isolated bronchi were challenged with platelet-activating factor (PAF). BNT162b2 increased resting tone and response to histamine, shifting the concentration-response curve leftward and enhancing the response to electrical field stimulation (EFS). mRNA denaturation did not alter these effects, suggesting that the effect is due to an excipient, possibly polyethylene glycol (PEG), rather than the active component.
Publisher
Vaccines
Published On
Jan 28, 2023
Authors
Antonella Caputo, Francesco Nicoli, Luigino Calzetta, Alfredo Chetta, Marina Aiello, Annalisa Frizzelli, Josuel Ora, Enrico Melis, Francesco Facciolo, Lorenzo Ippoliti, Andrea Magrini, Paola Rogliani
Tags
BNT162b2
COVID-19 vaccine
eosinophilic asthma
bronchi
histamine response
platelet-activating factor
polyethylene glycol

Related Publications

Explore these studies to deepen your understanding of the subject.

Evaluating the effectiveness of the Kidogo model in empowering women and strengthening their capacities to engage in paid labor opportunities through the provision of quality childcare: a study protocol for an exploratory study in Nakuru County, Kenya
Social Work

Evaluating the effectiveness of the Kidogo model in empowering women and strengthening their capacities to engage in paid labor opportunities through the provision of quality childcare: a study protocol for an exploratory study in Nakuru County, Kenya

K. Okelo, M. Nampijja, et al.

The effect of Chinese vaccine diplomacy during COVID-19 in the Philippines and Vietnam: a multiple case study from a soft power perspective
Political Science

The effect of Chinese vaccine diplomacy during COVID-19 in the Philippines and Vietnam: a multiple case study from a soft power perspective

R. J. L. V. Dijk and C. Y. Lo

Seeds and the city: a review of municipal home food gardening programs in Canada in response to the COVID-19 pandemic
Social Work

Seeds and the city: a review of municipal home food gardening programs in Canada in response to the COVID-19 pandemic

J. Music, L. Mullins, et al.

Assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US
Medicine and Health

Assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US

F. S, W. C, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny